Man's Haemoglobin

Tree structured fiber optics MANs

Thomas Vicary and the Anatomie of Mans Body

Dysfunction of prefrontal cortex in schizophrenia includes changes in GABAergic mRNAs, including decreased expression of GAD1, encoding the 67 kDa glutamate decarboxylase (GAD67) GABA synthesis enzyme. The underlying molecular mechanisms remain unclear. Alterations in DNA methylation as an epigenetic regulator of gene expression are thought to play a role but this hypothesis is difficult to tes...

Persistent fetal haemoglobin and falsely high glycosylated haemoglobin levels.

Some of the routine methods of measuring glycosylated haemoglobin depend on its difference in charge from haemoglobin A and do not distinguish between glycosylated haemoglobin and fetal haemoglobin. Two insulin dependent diabetics showed persistent discrepancies between their capillary blood glucose values and their glycosylated haemoglobin values measured by agar gel electrophoresis: the blood...

Observations on foetal haemoglobin.

Foetal haemoglobin exhibits a much greater resistance towards alkaline denaturation than does adult haemoglobin, thus constituting an important distinction between the two types of haemoglobin. The phenomenon was first described by Korber (1866), observed again by Kruger (1887-88), and subsequently studied in more detail by Bischoff (1926), Haurowitz (1929, 1930), and Brinkman, Wildschut and Wi...

Intra-erythrocytic haemoglobin crystals.

When investigating a newly discovered haemoglobin L, using Itano's solubility test (Itano, 1953), a resemblance to sickle cell haemoglobin was noticed inasmuch as solubility was not complete in 2.24 M phosphate buffer. This was later realized to be due to an artefact (see Ager and Lehmann, 1957), but at that time the cells containing haemoglobin L were tested for sickling by incubation with red...